In this paper, the effect of heavy metal pollution on the growth of microorganisms in water body has been briefly summarized. Meanwhile, microorganisms as the molecular recognition elements of microbial sensor are exposed into heavy metal pollutants inevitably in the application of the biosensors practical detection, which affect the accuracy of measuring and the service life of microbial sensor. According to this problem, we selected a methanotrophic ME25 as the research target, which is the molecular reco...