Eye drops was a traditional dosage form of eye treatment. The losses of drug was much, and drug entering eye was only 5% because of blinking eye movement and lacrimonasal duct drainage and so on. Puerarin(PUE), cmmonly ued in treatment of glaucoma, was chosen as the model drug. PAMAM could open intercellular tight junction and enhance the permeability cell membrane. We prepared PAMAM dendrimers-coated liposomes and the in-vitro transcorneal penetration, precorneal residence time, residual amount of puerarin...
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