AIMTo investigate whether endothelial progenitor cells (EPCs )are involved in the mechanism of low-molecular-weight heparin (LMWH )in treating cardiovascular disease. METHODSTotal mononuclearcells(MNCs)were isolated from peripheral blood by Ficoll density gradient centrifugation .Cells were plated on fibronectin -coated culture dishes .After 7Dculture ,attacted cells were stimulated with LMWH(to make a series of final concentrations:50,100, 200and400 KU/L~-1)or vehicle control for the respective time points...