骨保护素(osteoprotegerin,OPG)和核因子NF—κB受体激活剂(receptor activator of nuclear factor—κB,RANK)及其配体(receptor activator of nuclear factor—κB ligand,RANKL)是近年来发现的与骨吸收和重建密切相关的细胞因子,在关节炎骨破坏中起重要作用。RANKL和RANK结合可促进破骨细胞(osteoclast,OC)及其前体细胞分化成熟和活化;而OPG可阻断此过程而抑制RANKL介导的OC分化,从而减少骨质损害。
研究目的:本课题以骨关节炎(osteoarthritis,OA)和健康者为对照,通过观察类风湿关节炎(rheumatoid arthritis,RA)和强直性脊柱炎(ankylosing spondylitis,AS)患者滑膜、滑液和外周血中RANK、RANKL和OPG的表达、分布及与骨破坏的关系。进一步阐明RANK、RANKL和OPG系统在RA和AS关节骨侵蚀发生机制中的中心作用,为临床早发现、早评价骨破坏程度,早使用OPG预防骨破坏提供理论依据。
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【英文摘要】
Osteoprotegerin(OPG), receptor activator of nuclear factor—κB (RANK) and receptor activator of nuclear factor—κB ligand(RANKL) are the cytokines which have close relationship with the absorption and re-establishment of bones. The interaction between RANKL with RANK can promote differentiation and activation of osteoclasts and its precursor cells. This process can be blocked by OPG, which can decrease the bone destruction.Object: our study was performed to compare the expressions and distributions of RANK, R...
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