Cancer, a fatal disease to human life and health, is the top one factor for mortality in many countries. Oral cancer accounts for 3%, 5%, 40% in all sorts of cancers in Sweden, USA, Indian and Southeast-Asia, respectively. And that the 80% of the oral cancer is oral squamous cell carcinoma. Proanthocyanidins play chemopreventive or chemotherapeutic role to oral cancer, skin tumor, breast cancer, pancreatic tumor, prostatic cancer, liver cancer, lung carcinoma, gastric adenocarcinoma and colon tumor, thanks ...