Effects of Ghrelin on the Electric Activity of Gastric-ralated Neurons in the VMH and the Integration of Intra-VMH Ghrelin on the Food Intake in the Rats
Background: Ghrelin is a 28-amino acid endogenous peptide recently identified in the secretory granules of X/A-like cells in the rat stomach, which can act on the growth hormone secretagogue receptor to accelerate the secretion of growth hormone. It was identified that ghrelin-immunoreactive cell and its receptor localize in areas of brain, such as hypothalamus (VMH, PVN, ARC), hippocampus, adenohypophysis and so on. Motilin is a 22-amino acid peptide secreted from the upper part of the small intestine, whi...