Objective To detect the expressions of p21、p16 and p53 gene, and investigate their relationship in osteosarcomas. Methods SP immunohistochemical technique was used to detect the expressions and their relationship of p21、p16 and p53 gene among the 37 osteosarcomas. Result The positive rates of p21、p16 and p53 gene were 64.9%、40.5% and 45.9% respectively in 37 osteosarcomas, their positive rates and expressive intensities in osteosarcomas were higher ; their positive correlation was significantly observed ...