Backgrounds:
Signal transducers and activator of transcription,STATs, are a family of transcription factors that transduce signals from cell surface receptors directly to the nucleus.Activation of all the STAT proteins is caused by phosphorylation of a single tyrosine residue that leads to dimerization via an intermolecular SH2 phosphotyrosine interaction. The dimerized STATs then translocate to the nucleus where they regulate gene expression by binding directly to high affinity DNA binding si...