重症急性胰腺炎(severe acute pancreatitis,SAP)是临床上常见的危重急症,近年来其发病率有上升趋势,临床发病凶险、病情进展快、并发症多、预后差、死亡率高。其病因至今不清楚,而且缺乏有效的治疗手段。胃肠功能衰竭是SAP最常见并发症,常发生在其他脏器衰竭之前,既是多系统脏器衰竭(Multiple system organ Failure,MSOF)的一种局部表现,又是引发和加重MSOF的“动力部位”、“扳机因素”。大量临床证据证实及时预防和治疗胃肠功能衰竭,对减少和预防SAP时MSOF发生具有重要意义。
微生态制剂近年被逐渐用于研究改善肠,常用的微生态制剂包括益生菌、益生元以及合生元。研究发现其可通过直接补充机体的正常菌群或选择性刺激正常菌群的生长繁殖,从而抑制外源性致病菌和内源性条件致病菌的过度生长和繁殖,防止内源性感染的发生和发展,而且还具有保护肠屏障、促进肠蠕动等功能。但是目前还未见其对SAP肠衰竭方面的研究。本实验旨在研究微生态制剂培菲康(三联活菌制剂)、燕麦β-葡聚糖联合肠内营养对重症急性胰腺炎肠功能衰竭(包括肠屏障和肠吸收及运转功能)的作用。为防治SAP...
【英文摘要】
The severe acute pancreatitis(SAP) is a potential deathful disease,with the morbidity increased in recent years,which has a high mortality rate.The pathogenesis is not elucidated quite well until now,and there is no efficient treatment strategy.The gastrointestinal failure is the most frequence complications and often occurened before other organ's dysfunction.It is not only the local display,but also the trigger of developing and aggravating of the multisystem and organ failure(MSOF).More and more c...