Objective: Osteoporosis is the most common metabolic disease characterized by loss of the normal density of bone, resulting in fragile bone and a higher risk of fractures. Glucocorticoid-induced osteoporosis (GIO) is the most common form of secondary osteoporosis. However, recent studies have also demonstrated different or even contradictive outcomes on whether the glucocorticoids inhibit or increase biological activity of the skeletal cells. Our study is to determine the different influence of Dexa...