In this paper,the preparation of cantaloupe(Cucumis melo L.) fermented beverage by Lactobacillus bulgaricus and Streptococcus thermophillus were studied.Orthogonal test showed that the optimum formula of fermented beverage were:refined sugar 4%,milk powder 5%,fermentative temperature 42 ℃,inoculation quantity 4%,and fermentation time 48h.Compound stabilizer was made using 0.2% xanthan gum and carboxymethyl cellulose(CMC) with their ratio of 1:1.The product had exquisite feeling and unique flavor.