采用优化设计方法研究金属离子在林可链霉菌(Streptomyces lincolnensis)林可霉素生物合成中的交互作用,并应用均匀设计法,以最终发酵液的生物效价为目标函数建立模型,通过软件Uniform Design Version 3.00分析得出优化配比:FeSO4.7H2O 0.45g/L,CuSO4.5H2O 1g/L,MnCl21g/L;按优化方案添加金属离子,使发酵液的最终生物效价较原配方提高20%,明显提高了林可霉素的发酵水平。
【英文摘要】
An optimization design was utilized to study the combined effect of different supplemented metal ions on the biosynthesis of lincomycin(Streptomyces lincolnensis).Uniform design method was employed to obtain quadratic models for the titres of the final fermentation broth.Meanwhile,analytic software gave the optimum results: the addition of FeSO4·7H2O,CuSO4·5H2O and MnCl2 to the culture were 0.45,1 and 1 g/L respectively.The culture with metal salts according to the optimum scheme could improve the final bio...
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