Objective:To explore the model of inheritance of panic disorder. Method:75 genealogy with panic disorder were studied by segregation analysis and polygene threshold theory. Results:The correct segregation rate was 0.235.The weighted mean of the heritability of first-degree relatives was (79.17±4.39)%. Conclusion:The model of inheritance of panic disorder maybe a kind of polygene disease with a recessive major gene or conform to autosomal recessive inheritance.