Arsenic Trioxide Induces Differentiation of CD133~+ Hepatocellular Carcinoma Cells and Prolongs Posthepatectomy Survival by Targeting GLI1 Expression in a Mouse Model
BackgroundHepatocellular carcinoma (HCC) is the fifth most common cancer and the second leading cause of cancer death in men, and the seventh most common cancer and the sixth leading cause of cancer death in women in the world. At present, surgical resection is the first choice for treatment of HCC, but the long-term prognosis remains unsatisfactory; the tumor recurrence rate after resection of primary tumor is high, owing to the lack of an effective adjuvant therapy. Cancer stem cells (CSCs) play a key rol...
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