Background and purpose Vascular disease are main life-threatening comeplex in world. Arterial interventional therapy such as balloon angioplasty and stenting is presently a potential strategy against coronary and cerebral artery disease. However, the efficacy of these techniques is limited by restenosis ( ie, the recurrence of the treated lesions, in 20% to 50% of procedures). Several lines of evidence indicate that this restenosis might be multifactorial and caused mainly by vascular remodeling, the migra...