Human papillomaviruses are nonenveloped double-stranded DNA tumor viruses.Over 90% of all cervical cancers have been found HPV positive,with particular high-riskHPV types(16,18,31,etc)mostly commonly found. The genomic organiziton of HPV have been established. They comprise upstream regulate region(URR), early region and(E) and later region(L). The early region have eight open read frames(ORFs), E6,E7,El,E8,E2,E4,E3,and E5 respectively.The high-risk HPV E6 and E7 oncoprotein exert profound effect...
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