Glutathione S-transferases (GSTs, EC2.5.1.18) are a superfamily of multifunctional enzymes found in almost all living organisms. They were first discovered in animals in 1961 where they were postulated to play a role in the detoxification of drugs. The main function of GSTs is to catalyze nucleophilic attack by reduced glutathione (GSH) on nonpolar compounds that contain an electrophilic carbon, nitrogen, or sulphur atom. Mammalian GSTs are particularly well studied due to their role in cancer epidemi...