Interaction between biomaterials and tissues occurs via a layer of proteins adsorbed at the surface of biomaterials, which is the immediate event occurring on its first contact with biological fluids and tissues. The nature and amount of the protein or polysaccharide adsorption layer depends on material surface properties, such as wettability, polar or ionic interactions, chemical structures and topography of the surface. The surface determines essentially the biocompatibility whereas the bulk decides the p...
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