Liver plays a critical role in first-line defense against foreign antigens that enter via the portal veins. The hepatic immune system maintains a well-controlled balance between tolerance and initiation of an immune response. The immune constitution of liver is quite distinct from other tissue or organs, containing a large proportion of resident innate immune cells such as macrophages, NK cells and NKT cells. The considerable abundance of these populations in liver implies important roles of these cell type...
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