节点文献
Microwave-assisted bromination of pyrimidine derivatives in water
【Author】 Qu Guirong Han Suhui Zhang Zhiguang Geng Mingwei Xue Feng College of Chemistry and Environmental Science Henan Normal University Xinxiang 453007
【摘要】 <正>The facile bromination of pyrimidine derivatives with Br2 in water under microwave irradiation is described. The desired 5-bromo pyrimidine derivatives (2a-e) were obtained within 10 minutes in 54-94% yields. Deacetylation was observed when starting materials with acetyl protecting groups (1c,1f,1g) were applied to this protocol and the possible reason was that the strong acidic surroundings, aroused by HBr generated during the reaction, made the cleavage of Ac-O(N).
【基金】 Project supported by the National Natural Science Foundation of China (No. 20372018).
- 【会议录名称】 第七届全国磷化学化工暨第四届海峡化学生物学、生物技术与医药发展讨论会论文集
- 【会议名称】第七届全国磷化学化工暨第四届海峡化学生物学、生物技术与医药发展讨论会
- 【会议时间】2006-04
- 【会议地点】中国河南郑州
- 【分类号】O621.255
- 【主办单位】中国化学会、国家自然科学基金委