A New Method of Deoxygenation in the Synthesis of Taxanes by Hypophosphorous Acid

【Author】 GU, Jun ZHANG, Meng YIN, Da-Li(Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050)

【摘要】 <正> Based on the chemistry involved in the radical chain deoxygenation of alcohols by the Barton-McCombie reaction, numerous applications in the synthesis of taxanes were reported. In the original Barton-McCombie method, tributyltin hydride was the hydrogen atom source and tributyltin radical generated from the hydride served as a chain carrier. Although the method gave the good yield and found many applications, the problems associated with the price, toxicity and removal of tin residues prompted search for other hydrogen atom sources. Radical chain deoxy-更多还原