Effects of Surface Microtopology and Membrane Stiffness on Kinetics of Selectin/Ligand Interactions by a Modified BFP

【Author】 Botao shaw, Mian long1. College of Bioengineering, Chongqing University, Chingqing, China, 400044;2. NMLC, Institute of Mechanics, Chinese. Academy of Sciences, Beijing, China, 100080;

【摘要】 <正> More and more evidences come out to support that the functionality of adhesion molecules are influenced by the surface microtopology of cell carrier or substrate. Adhesive molecules usually express on the microvilli of a cell, providing a well-defined spatial configuration to mediate the adhesions to the counterpart molecules on the apposed surface. In a pioneering work, comparisons were done by using immunoglobin (IgG) binding to their counterpart receptors CD16 expressed onto the membrane of transfected K562 cells (rough surfaces) and coated onto the surface of human red blood cells (smooth surfaces), respective更多还原