【摘要】 目的探讨丹红注射液对不稳定型心绞痛(UA)病人血浆炎症反应物及纤溶活性的影响。方法140例UA病人随机分为常规治疗组(67例)和丹红治疗组(73例),另设正常对照组50名。丹红治疗组于常规治疗基础上加用丹红注射液20mL静脉输注,每日1次,疗程为3周。两组分别于治疗前及结束时测定血清C-反应蛋白(CRP)、白细胞介素-6(IL-6)、纤维蛋白原(FIB)、D-二聚体(DD)浓度和组织型纤溶酶原激活物(t-PA)、纤溶酶原激活物抑制物-1(PAI-1)活性。结果丹红注射液治疗3周后,CRP,IL-6,FIB,DD,PAI-1水平下降(P<0.05或P<0.01),t-PA活性升高(P<0.01)。治疗前UA病人的CRP与IL-6,PAI-1,DD呈正相关(P<0.05或P<0.01),与t-PA呈负相关(P<0.01)。丹红治疗组治疗后CRP与IL-6,PAI-1呈正相关(P<0.05或P<0.01),与t-PA呈负相关(P<0.05)。结论UA病人应用丹红注射液治疗,可能有利于抑制炎症反应,改善内皮功能,提高纤溶活性,稳定斑块。更多还原

【Abstract】 Objective To explore the effect of Danhong injection on serum inflammatory reactants and fibrinolytic activity in patients(pts) with unstable angina(UA).Methods One hundred and forty patients with UA were randomly divided into routine treatment group(n=67) and Danhong treatment group(n=73) treated with Danhong injection.Fifty healthy subjects were as controls.Fasting serum C-reactive protein(CRP),interleukin-6(IL-6),fibrinogen(FIB),tissue-type plasminogen activator(t-PA),plasminogen activator inhibitor-1(PAI-1) and D-dimer(DD) levels were measured before and after the treatments.Results Comparison with healthy controls,the levels of CRP,IL-6,FIB,DD and PAI-1 were higher(P<0.05 or P<0.01),and t-PA was lower(P<0.01) in pts.Following treatment of Danhong injection,CRP,IL-6,FIB,DD and PAI-1 were decreased,t-PA was increased(P<0.05 or P<0.01).There were no differences in routine group before and after treatment.Correlation analysis showed that CRP was positively correlated with IL-6,PAI-1 and DD(P<0.05 or P<0.01),correlated inversely with t-PA(P<0.01) in pts before treatment;CRP was correlated positively with IL-6 and PAI-1(P<0.01) and correlated inversely with t-PA(P<0.05) in the Danhong group.Conclusion Danhong injection might be benefit to inhibit inflammatory responses,improve endothelial function,increase fibrinolytic activity and stabilize atherosclerotic plaque in pts with UA.更多还原