【摘要】 目的研究银可醇软胶囊对四氯化碳及D-氨基半乳糖所致急性肝损伤的保护作用。方法:采用0.5%四氯化碳的橄榄油(10ml/kg)、D-氨基半乳糖(D-Gal,800mg/kg)分别ip造成小鼠和大鼠急性肝损伤模型,ig不同剂量的银可醇软胶囊,测定血清中谷丙转氨酶(ALT)、谷草转氨酶(AST)的活性,观察肝组织的病理改变。结果:银可醇软胶囊能明显降低CCL4及D-Gal引起的鼠血清ALT和AST升高,减轻肝组织损伤程度。结论:银可醇软胶囊对肝损伤有明显的保护作用。更多还原

【Abstract】 Objective :To study the protective effect of Yinkechun soft capsules on acute liver injury induced by carbon tetrachloride and D-galactosamine.Methods :The acute liver injury model induced by 0.5 % CCl4 in olive oil(10 ml/kg)or D-galactosamine(800 mg/kg)ip was established in mice or rats.Yinkechun 10、40 and 160 mg/kg was administered ig. To study the protective effect for different doses of Yinkechun, ALT and AST in serum were analysized, and liver injury was oberserved by patholoyical examination. Results :Yinkechun can reduce significantly the increase of ALT and AST in serum and liver injury induced by carbon tetrachloride and D-galactosamine. Conclusion : Yinkechun soft capsules has a powerful protective effect on acute liver injury induced by carbon tetrachloride and D-galactosamine.更多还原