【摘要】 目的探讨GnRH antagonist治疗PCOS病人的IVF-ET结局。方法将2006年4月至6月42例临床诊断为PCOS的病人随机分为两组:GnRH antagonist治疗组18人和GnRH agonist长方案对照组24人,记录促性腺激素的用量及其用药天数,获卵数,受精率,卵裂率,HCG日子宫内膜厚度和雌激素水平,周期取消率,妊娠率,OHSS发生率等。结果两组促性腺激素的用量及其用药天数、获卵数、受精率和卵裂率相比较均无显著差异。在hCG日的雌激素水平明显降低,子宫内膜是增厚的,其差异有统计学意义(P均<0.05),妊娠率和着床率经χ2检验,结果差异有统计学意义(P<0.05)。结论GnRH antagonist治疗PCOS妊娠率和着床率均升高的,而卵泡的发育、卵母细胞的受精率和卵裂率不受影响。E2水平明显低于对照组可能为影响着床率和妊娠率的主要因素,GnRH antagonist用药是安全和高效的,为促排卵提供了新选择。更多还原

【Abstract】 Objective:To investigate the effect of the protocol of gonadotropin releasing hormone antagonist on the outcome of PCOS patients who underwent in vitro fertilization.Methods: PCOS patient who subjected to IVF between April 2006 and July 2006 were divided randomly into two group:the study group:eighteen patients with PCOS were subjected to a protocol of gonadotropin-releasing hormone antagonist.The control group:twenty-four patient with pcos were subjected to a long protocol of gonadotropin-releasing hormone agonist.To record the doses of gonadotrophins(HMG and/or rFSH),the during of administration,the number of retrieved oocyte,the ratio of fertilization,the ratio of cleavage,the thick of endometrium and the profile of serum E2 on the day of HCG administration,Cycle cancellation rate,Implantation rate of embryo,Pregnantion rate and the incidence rate of OHSS.Results: The two groups were similar with respect to the doses of gonadotrophins(HMG and/or rFSH),the during of administration,the number of oocyte retrieval,the ratio of fertilization,the ratio of cleavage,and the incidence rate of OHSS.Significant differences(P<0.05) were found regarding pregnant rate,implantation rate of embryo,and the profile of serum E2 by analyzing statistically(Student′s t-test and χ2-test).Conclusion: We demonstrated that GnRH antagonist administration in PCOS patients undergoing IVF did not impact the development of follicle and alter the oocyte competence.The pregnancy rate and the implantation rate were increased,most likely,Owing to increasing endometrial receptivity.in addition,the profile of serum E2 was reduced,which decreased the incidence of OHSS.These result demonstrated the high performance and safety of this drug on controlled ovarian stimulation protocol.The protocol was optimal更多还原