【摘要】 目的:研究盐酸青藤碱脂质体的最佳制备工艺。方法:采用超声波分散法制备盐酸青藤碱脂质体,通过正交实验设计,以包封率为考察指标筛选工艺。结果:优选实验因素:磷脂量(w/v)为6%、盐酸青藤碱与磷脂的比例量(w/w)为l:8、胆固醇与磷脂的比例量(w/w)为1:7、溶液的pH为8.2。该选优工艺下,脂质体平均包封率为65.75%,RSD为2.51%(n=5)。结论:该优选工艺条件可行。更多还原

【Abstract】 Objective:To study the best preparation techniques of sinomenine hydrochloride liposome.Method:The sinomenine hydrochloride hposome was prepared by ultrasonic dispersing method with orthogonal design.Result:Experimental factors:phospholip- id was 6%(w/v).The ratio of sinomenine hydrochloride to phospholipid was 1:8(w/w).The ratio of ehoesterin to phospholipid was 1:7(w/w),and the pH was 8.2.The average entrapment efficiency of liposome was 65.75%,and the RSD was 1.82%(n=5). Conclusion:The preparation techniques of sinomenine hydrochloride liposome by ultrasonic dispersing method with orthogonal design was suitable,and it established the foundation for the extended-release preparation study.更多还原