【摘要】 目的研究制蚜菌素对SD大鼠的亚慢性经口毒性。方法按照GB 15670-1995《农药登记毒理学实验方法》,设为0.0、2.4、9.6、38.3 mg/kg饲料4个剂量组,每组20只大鼠,雌雄各半;分别采用无明显损害作用剂量(NOAEL)和基准剂量(BMD)计算亚慢性经口毒性阈值。结果大鼠亚慢性经口毒性试验显示,高、中剂量组肝重、肝脏器系数及摄食量低于对照组,差异有统计学意义,且均存在剂量-效应关系,呈负相关。结论制蚜菌素原药亚慢性经口毒性NOAEL雌雄性大鼠分别为(0.22±0.02)、(0.18±0.01)mg/(kg.d),BMD的95%可信限下限(BMDL)雌雄性大鼠分别为0.790、0.319 mg/(kg.d)。更多还原

【Abstract】 [Objective] To study the sub-chronic oral toxicity of biologic pesticide aphicidin in rats.[Methods]According to the GB 15670-1995 "Toxicological Testing Methods for Pesticide Registration",four dose groups(0,2.4,9.6 and 38.3 mg/kg of feed) were established with 20 rats(10 males and 10 females) in each group;the sub-chronic toxicity threshold value was calculated using NOAEL and benchmark dose(BMD) respectively.[Results]The liver weight,liver-body coefficient and total food consumption of the high and middle dose groups were lower than that of the control group,the difference indicated statistic significance and negative dose-effect correlations.[Conclusion]The NOEL of aphicidin sub-chronic toxicity were(0.18±0.01)mg/(kg.d) and(0.22±0.02)mg/(kg.d) among females and male rats respectively;the BMDs were 0.790 mg/(kg.d) and 0.319 mg/(kg.d) among female and male rats respectively.更多还原