【摘要】 目的探讨新辅助化疗(NACT)在子宫颈癌治疗中的应用价值。方法选择2000年1月—2005年12月连云港市第一人民医院收治的42例宫颈癌患者,所有患者术前均行2个疗程化疗(间隔21d),化疗方案为PVB或BIP,化疗后2周进行手术根治。结果NACT总有效率为78.6%,其中完全缓解28.6%,部分缓解50.0%,局部肿瘤体积缩小显著,术后病理显示宫颈残留42.2%,宫旁浸润4.8%,盆腔淋巴结转移7.1%。患者术后恢复良好,有宫颈残留、宫旁浸润、盆腔淋巴结转移者,术后行局部放疗或术后巩固化疗,29例患者已随访3a,死亡3例,其余正随访中。结论NACT作为宫颈癌患者术前治疗是安全有效的,可以缩小肿瘤体积,提高手术成功率。更多还原

【Abstract】 [Objective] To explore the application value of new pre-operation auxiliary chemotherapy (NACT) in treating cervical carcinoma. [Methods] Two periods of chemotherapy were conducted on 42 cervical carcinoma patients who were collected since January of 2001 to December of 2005 (every 21 days); the chemotherapy projects were PVB and BIP; operation was made two weeks afterwards. [Results] The total effective rate of NACT was 78.6%, 28.6% of which was complete remission; 50.0% of which was partial remission; local carcinoma bulk decreased significantly; the post-operation pathology indicated that there was 42.2% of cervical remains, 4.8% of uterus infiltration and 7.1% of pelvic cavity lymph node metastasis. Those patients received local radiotherapy and chemotherapy after the operation, 29 patients was followed up for 3 years, 3 of them died. [Conclusion] NACT is safe and effective for the pre-operation treatment of cervical carcinoma, which can reduce the carcinoma bulk and increase the successful rate of the operation.更多还原