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不锈钢微针经皮给药的研究

Transdermal drug delivery using stainless steel microneedle array

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【作者】 郑静南陈华兵张俊勇杜丹荣朱丹丹牟东升杨祥良赵英俊

【Author】 ZHENG Jing-nan1,CHEN Hua-bing1,ZHANG Jun-yong2,DU Dan-rong3,ZHU Dan-dan1,MOU Dong-sheng3,YANG Xiang-liang1,ZHAO Ying-jun2(1 Institute of Materia Medica,College of Life Science and Technology;2 School of Mechanical Science and Engineering;3 Department of Chemistry;Huazhong University of Science and Technology,Wuhan 430074,China)

【机构】 华中科技大学生命科学与技术学院药物研究所华中科技大学机械科学与工程学院华中科技大学化学系华中科技大学机械科学与工程学院 武汉430074武汉430074

【摘要】 目的:将不锈钢微针阵列应用于经皮给药。考察离体大鼠皮肤经不同针形微针预处理相同时间、相同针形微针预处理不同时间后,模型药物鬼臼毒素经大鼠皮肤的透皮能力。方法:微针预处理大鼠皮肤后,用改进的Franz扩散池研究鬼臼毒素对皮肤的透皮速率。高效液相色谱法测定鬼臼毒素的含量。结果:皮肤经微针预处理后进行鬼臼毒素透皮,其透皮速率比未经微针处理时有明显提高。三角形微针、梯形微针、矛形微针对鬼臼毒素的促渗能力依次增强;三者所引起的鬼臼毒素在皮肤中的滞留量有显著差异。同种针形微针预处理皮肤时间越长,鬼臼毒素的透皮速率越大;但微针预处理时间对皮肤中的药物滞留量无显著影响。结论:微针用于药物经皮给药时,微针针形、微针的预处理时间对药物的经皮渗透具有重要影响。

【Abstract】 Objective:To investigate the permeability of podophyllotoxin across the isolated rat skin following applying different needle-shapes of the stainless microneedle array as a transdermal delivery system and different skin pretreating time-points.Methods:The in vitro permeation rates of podophyllotoxin were measured using a Franz diffusion cell fitted with the pretreated rat skins by microneedles.Podophyllotoxin was measured by HPLC.Results:The permeation rates of podophyllotoxin across the skin pretreated with microneedles were higher as compared to those of the untreated.The lanciform microneedles resulted in the highest permeation rate and triangular microneedles had the lowest one.The amount of drug accumulated in the pretreated rat skins was significantly different after applying the different needle-shapes of microneedles.When skins were pretreated using microneedles with the same needle-shape for various time-points,the drug permeation rates were increased with the increase of time.However,the increase of pretreating time had no significant influence on the accumulated amount of drug in skin.Conclusion:The needle-shape and skin pretreating time of the microneedles play the important roles for the transdermal drug delivery.

【关键词】 微针经皮给药鬼臼毒素
【Key words】 microneedlestransdermal drug deliverypodophyllotoxin
  • 【文献出处】 中国新药杂志 ,Chinese Journal of New Drugs , 编辑部邮箱 ,2007年11期
  • 【分类号】R94
  • 【被引频次】21
  • 【下载频次】552
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