【摘要】 目的:采用红外光谱法测试氟尿嘧啶植入剂的高温融熔生产工艺对药物结构的影响。方法:测试该植入剂及各配方成分的红外光谱图,以标准谱图比对,检查因结构变化而形成的吸收峰变化。结果:该植入剂图谱中各配方成分的特征峰呈叠加状态,未增加或减少一峰,未出现明显变化。结论:高温融熔工艺对氟尿嘧啶植入剂结构没有明显影响。更多还原

【Abstract】 Objective:To evaluate whether the high-temperature fusion impacts stability of fluorouracil(5-Fu) implants by infrared spectroscopy(IR).Methods:A comparison of the IR spectra of various implant formulae containing 5-Fu with the standard IR spectra was conducted.Results:All characteristic peaks in the IR spectra of each implant formulae showed high coincidence.Conclusion:The high temperature fusion has no impacts on the stability of 5-Fu implants.更多还原