【摘要】 P53在肿瘤的发生发展中占有重要地位。近来,越来越多的学者注意到p53对肿瘤细胞的耐药性也具有一定影响。现从P53自身稳定性、下游靶基因的活化及P53与其他分子/基因相互作用3个方面对其在肿瘤耐药性分子机制研究的进展进行简要阐述。更多还原

【Abstract】 As well known,roles of P53 gene have been extensive in the formation and development of tumors.Recently,it has been found that the P53 is associated with a drug resistance to tumors.This article highlights research progresses of molecular mechanism of P53 in the role of the drug resistance with respect to the homeostasis and the activation of downstream target genes of P53 as well as the interactions of P53 with other molecules/genes.更多还原