【摘要】 目的:观察颈动脉粥样硬化(CA S)合并斑块伴脑供血不足患者使用灵蒲合剂治疗前后脑血流动力学的变化。方法:给予62例CA S合并斑块伴脑供血不足患者服用灵蒲合剂治疗1个月,治疗前后采用经颅多普勒超声(TCD)检测颅内双侧大脑中动脉、大脑前动脉、大脑后动脉、椎动脉及基底动脉的平均血流速度(Vm)和搏动指数(P I),并与30例老年健康体检者进行对照。结果:与健康对照组比较,治疗组治疗前各血管Vm均明显降低(P<0.05或P<0.01),且多数血管P I明显升高(P均<0.05)。治疗后治疗组各血管Vm较治疗前有显著性增高(P<0.05或P<0.01);且P I较治疗前均明显降低(P均<0.05)。结论:灵蒲合剂可改善CA S合并斑块伴脑供血不足患者的脑供血,且无不良反应,是治疗CA S合并斑块伴脑供血不足的有效组方。更多还原

【Abstract】 Objective:To study the change of brain blood stream of carotid atherosclerosis and plaque patients before and after the treatment of Lingpu mixture(灵蒲合剂) on carotid atherosclerosis(CAS) and plaque.Methods:Sixty-two patients in treatment group were treated by Lingpu mixture for one month.The changes of velocity mean(Vm) blood and pulse index(PI) of two sides middle cerebral artery,anterior cerebral artery,posterior cerebral artery vertebral artery and basilar artery were checked by transcranial Doppler (TCD),and compared with healthy old men(n=30) before and after the treatment.Results:In the treatment group,Vm of blood stream in all vessels were lowered significantly than healthy control group before the treatment(P<0.05 or P<0.01),PI in many vessels were significantly elevated(all P<0.05).After treatment,Vm of blood stream in all vessel in the treatment group were improved significantly(P<0.05 or P<0.01),and PI were lowered significantly(all P<0.05).Conclusion:The Lingpu mixture can improve the brain blood stream of CAS and plaque patients with blood insufficient of brain,and without adverse side effect.It is an effective prescription on the treatment of CAS and plaque.更多还原