【摘要】 目的研究普伐他汀对急性冠脉综合征患者血浆一氧化氮、[凝血]因子Ⅰ、D-二聚体水平的影响。方法随机选择急性冠脉综合征患者135例,入选病人随机单盲分为普伐他汀组69例,常规治疗组66例,另外随机选择50例正常人做对照组。采用比色法测定一氧化氮含量;血凝仪法测定[凝血]因子Ⅰ含量;胶体金法测定D-二聚体含量。结果急性冠脉综合征患者血浆一氧化氮水平明显下降,与对照组比较差异有显著性(P<0.01);血浆纤维蛋白原、D-二聚体水平明显升高,与对照组比较差异有显著性(P<0.01);普伐他汀组和常规治疗组两组治疗前3者水平比较差异无显著性(P>0.05)。普伐他汀组治疗后一氧化氮水平较前明显升高,[凝血]因子Ⅰ、D-二聚体水平较前明显降低,与治疗前比较差异有显著性(P<0.01),与常规治疗组治疗后比较差异也有显著性(P<0.01);结论普伐他汀可通过保护血管内皮功能及改善血液流变学状态,从而改善心肌供血,抑制急性冠脉综合征的发生发展过程。更多还原

【Abstract】 Objective To study the effects of Pravastatin on the levels of plasma nitrogen monoxidum,fibrinogen and D-dimer in patient of actue coronary syndrome. Methods One hundred and thirty-five patients of actue coronary syndrome were randomly recruited and divided into 2 groups: the Pravastatin therapeutic group (n =69) and conventional therapeutic group (n =66); The other 50 healthy people were recruited as control group. The levels of plasma nitrogen monoxidum were determined with colorimetry. The levels of plasma fibrinogen were determined with automated coagulometer method. The level of D-dimer was dertermined with colloidal gold method. Results The levels of plasma nitrogen monoxidum decreased significantly and the levels of Fibrinogen and D-dimer increased significantly in the patients of actue coronary syndrome compared to those in control group (P <0.01,P <0.01,P <0.01). There was no significant differences in the levels of plasma nitrogen monoxidum,fibrinogen and D-dimer between the Pravastatin therapeutic group and conventional therapeatic group (P >0.05) before the treatment. After 8-week Pravastatin therapy,the levels of plasma nitrogen monoxidum increased significantly; the levels of plasma fibrinogen and D-dimer decreased significantly (P <0.01). There was no significant differences in the conventional therapeutic group (P >0.05). Conclusion It is suggested that the therapy with Pravastatin could protect vascular endothelial function,improve the blood supply of cardiac muscle,and inbibit the process of actue coronary syndrome.更多还原