【摘要】 目的探讨儿童重症肌无力的手术疗效和适应证。方法回顾性分析182例行扩大胸腺切除术的儿童重症肌无力患者的临床资料。结果1、3和5年的缓解率为18.6%、35.8%和42.7%,有效率为77.6%、82.9%和86.7%。单纯眼肌型在第3、5年的有效率分别为86.5%、92.0%,明显高于全身型的患儿(P<0.05),其有效率分别为73.0%、76.0%。结论胸腺切除术对治疗儿童重症肌无力是安全有效的,胸腺瘤和全身型重症肌无力患儿应尽早手术,单纯眼肌型可先予保守治疗,如1年后药物控制不佳亦应行手术治疗。更多还原

【Abstract】 [Objective] To invesgate the surgical effect and indictation of children with myasthenia gravis. [Method] The clinical information of 182 children with myasthenia gravis after thymectomy were retrospectively analyzed. [Result] The remission rate was 18.6%, 35.8%, 42.7% respectively during the follow up at the year of 1,3,5; and the effective rate was 77.6%, 82.9%, 86.7% respectively. For the patients with ocular type, the effective rate of 3,5 year was 86.5%, 92.0%; while those with general type was 73.0%, 76.0%. There was significant difference between these two sub-groups (P <0.05). [Conclusions] Thymectomy is effective and safe for children myasthenia gravis. Thymectomy is recommended for children with thymoma and general myasthenia gravis. For the ocular type, conservative therapy is proper. And the surgical is also recommended if there is no effect of drug therapy after 1 year.更多还原