【摘要】 目的对多肽生长因子对牙周膜细胞(periodontal ligament cell,PDLC)影响的研究进行综述。方法广泛查阅近年国内外多肽生长因子对牙周膜细胞影响的相关文献,并进行回顾与综合分析。结果PDLC的增殖和多向分化是牙周组织再生的基础。多肽生长因子对PDLC功能影响的研究成为牙周组织再生研究的热点之一。多肽生长因子在PDLC的移行、生长、增殖、分化、蛋白质和基质合成上均起着重要作用。结论多肽生长因子可应用于牙周组织的再生治疗,但还需进一步深入研究。更多还原

【Abstract】 Objective To evaluate the effects of the polypeptide growth factors on the periodontal ligament cell(PDLC) based on a comprehensive review on the literature concerned. Methods The recent literature related to the effects of the polypeptide growth factors on the PDLC were extensively and comprehensively reviewed and a corresponding evaluation was made. Results The proliferation and the multi-directional differentiation of the PDLC were found to be the basis for the regeneration of the periodontal tissues. The effects of the polypeptide growth factors on the function of the PDLC became a hot issue of the research on the regeneration of the periodontal tissues. The polypeptide growth factors were found to play an important role in the migration, growth, proliferation, differentiation, and synthesis of protein and matrix of the PDLC. Conclusion The polypeptide growth factors can be used in the periodontal regeneration treatment, but a further research is still required to improve this kind of treatment.更多还原