【摘要】 目的探讨奥氮平治疗脑外伤后急性谵妄综合征的疗效。方法对76例谵妄病人使用奥氮平治疗并进行前瞻性研究,所有病人随机分为实验组和对照组,使用CCMD-3器质性精神障碍诊断标准和DSM-IV谵妄诊断标准,临床总体印象量表严重程度(CGI-SI)和简明精神病评定量表(BPRS)及GCS昏迷评分标准进行临床评价。结果76例病人中67例进行了完整的评测,其中实验组35例,总有效率85.71%;对照组32例,总有效率37.50%。仅3例出现了恶心、皮疹等副作用,减药后缓解。结论奥氮平能有效控制脑外伤后急性谵妄综合征,同时不影响病人意识的观察,起效快、安全性高。更多还原

【Abstract】 Objective To study therapeutic efficacy of olanzapine for acute delirium after brain trauma.Methods Seventy-six cases were enrolled in the prospective study.All the patients were randomly divided into the experimental group and control group,Chinese Classification of Mental Disorders Version 3(CCMD-3)and DSM-IV were adopted as the diagnostic criteria of delirium,and BPRS,CGI-SI,and GCS were used to assess the clinical effect.Results Among the 76 cases,67 had the integrated data,35 were in the experimental group with an overall efficiency of 85.71%,and 32 were in the control group with an overall efficiency of 37.50%.Only 3 cases had such side effects as nausea and rashes,and the symptoms were relieved after reducing the dose.Conclusion Olanzapine can effectively control acute delirium after brain trauma with a high efficiency and safety,and has no affect on the observation of patients.更多还原