【摘要】 目的探讨冠心病患者发生阿司匹林抵抗的概率以及相关影响因素方法79名冠心病患者服用阿司匹林(100mg/d)7天以上,分别用ADP和AA作诱导剂,检测血小板聚集功能。结果用光学法(广为使用的方法)测定血小板聚集功能,阿司匹林抵抗发生率为11.4%(n=9)。阿司匹林抵抗组高血压患者的比率(44.4%)与阿司匹林敏感组(25.0%)比较有显著差别(P=0.01)。结论对服用阿司匹林的患者要检测其血小板聚集功能。高血压患者易发生阿司匹林抵抗,这提示这类患者要调整抗血小板药物,加大阿司匹林的剂量或换用其他抗血小板药物。更多还原

【Abstract】 Objective To investigate the accidence of aspirin resistance and associated affected factor in the coronary disease patients.Methods Seventy-nine coronary disease patients took aspirin(100 mg/d) for at least seven days.The patients’ platelet aggregation function were evaluated by adenosine disphosphate(ADP) and arachidonic acid(AA).Results Using the optical platelet aggregation(a widely accepted method),The prevalence of aspirin resistance was 11.4%(n=9).The ratio of hypertension patients in aspirin resistance group(44.4%) was higher than in aspirin sensitive group(25.0%)(P=0.01).Conclusion Platelet aggregation function of the patients on aspirin were measured.Hypertension patients tend to resist aspirin,which hint us that these patients need to adjust antiplatelet agents:increase aspirin dose or take other antiplatelet drug.更多还原