【摘要】 目的探讨基质金属蛋白酶MMP-2、MMP-7在胃癌组织中的表达、侵袭及转移的关系。方法应用免疫组化SP法检测87例胃癌组织、癌旁组织及正常胃组织中MMP-2、MMP-7的表达情况。结果MMP-2、MMP-7在正常胃组织表达率为阴性,在癌旁组织中有低表达,分别为18.4%、21.8%,在胃癌组织中表达率明显增高,且表达率的高低与淋巴结转移、分化程度、浸润程度呈密切相关性(P<0.05)。且MMP-2、MMP-7在胃癌组织中表达具有相关性。结论MMP-2、MMP-7在胃癌组织中的高表达且两者呈正相关,并对胃癌的预后判定有一定意义。更多还原

【Abstract】 Objective To study the significance of MMP-2、MMP7 protein expression and the relationship with invasion、 differentiation and and metastasis in human gastric carcinoma.Methods MMP-2、MMP-7 expression were examined by immunobistochemical S-P staining method in 87 cases of human gastric carcinoma、para-carcinoma and normal tissue.Results MMP-2、MMP-7 were negtive of in the normal tissue,and low expression in para-carcinoma,respectively18.4%、21.8%.The overexpression of MMP-2 、MMP-7protein were found in gastric carcinoma,and the expression was highly related with lymphonode metastasia、differentiation and invasion degree(P<0.05).Conclusion MMP-2、MMP-7 were highly expressed in gastric carcinoma,and the expression of MMP-2 was significantly correlated with MMP-7.Expression of MMP-2,MMP-7 is strongly associated with tumour progression、differentiation and and lymphonode metastasis in gastric cancer.Therefore MMP-2 、MMP-7 may be clinically useful as predictor of patients surviva1.更多还原