【摘要】 对小鼠腹腔注射肾上腺素造成实验性心源性肺水肿动物模型,观察S-亚硝基谷胱甘肽(GSNO)对肺水肿的防治作用。结果显示,与阳性对照相比,GSNO预防组和治疗组小鼠存活率极显著提高(P<0.01),肺指数极显著降低(P<0.01),肺组织的病理变化也明显减轻。提示:GSNO对心源性肺水肿具有明显的预防和治疗作用。更多还原

【Abstract】 To investigate the preventive and therapeutic effects of S-nitrosoglutathione on pulmonary edema in mice,the models of experimentally cardiogenic pulmonary edema induced by peritoneal injection with adrenaline hydrochloride were used in this study.The results showed that the survive rates of the groups with GSNO as preventive and therapeutic drugs were both significantly higher than that of the positive control group(P<0.01),and the pulmonary indexes were significantly lower(P<0.01) and the pathological changes were more alleviated than that of the positive control group.The results indicated that GSNO had an obvious preventive and therapeutic effects for experimentally cardiogenic pulmonary edema.更多还原