【摘要】 【目的】探讨眼前段光学相干断层扫描仪(AC-OCT)测量中央角膜厚度(CCT),并与光学相干断层扫描仪(OCT)进行比较。【方法】分别用OCT和AC-OCT的高分辨单线扫描程序(High Resolution Corneal)、角膜地形图程序(Pachymetry Map)测量30例(30只眼)正常受试者的CCT。采用配对t检验对之进行比较;用相关分析方法分析两种仪器测量值之间的相关性;随机选择1只眼分别用两种OCT仪依次重复测量CCT10次,采用变异系数作为评判标准,比较测量的可重复性。【结果】OCT测量的CCT平均值为526.0(s=29.4)μm;AC-OCT角膜地形图程序测量的中央2mm区域最小值、最大值和平均值的均值分别是512.6(s=31.7)μm,522.0(s=32..3)μm和515.0(s=31.7)μm,高分辨单线扫描程序测得的CCT值为518.9(s=31.1)μm;OCT测量的CCT值比AC-OCT的各测量值分别大13.3(s=5.9)Vm(P=0.000);3.9(s=6.3)μm(P=0.002);11.0(s=5.9)μm(P=0.000);7.0(s=6.4)μm(P=0.000)。OCTCCT与AC-OCT各CCT值有很好的相关性(rOCT—AC-OCTMin=0.987,rOCT—AC-OCTMax=0.987,rOCT—AC-OCTMean=0.988,rOCT—AC-OCTFlap=0.986,P均=0.000)。OCT测量CCT值10次的变异系数为0.67%。AC-OCT角膜地形图中央2mm区域中的最小值、最大值和平均值以及高分辨单线扫描程序测量值的变异系数分别为0.23%,0.48%,0.20%和0.37%。【结论】OCT测量的CCT值比AC-OCT的各CCT值大,两种OCT的测量值相关性较好;AC-OCT测量CCT的可重复性稍好于OCT。更多还原

【Abstract】 [Objective] To investigate the difference of central corneal thickness(CCT) measured by optical coherence tomography(OCT), anterior chamber-optical coherence tomography(AC-OCT),and compare their repeatability. [Methods]The CCT of 30 eyes of 30 normal persons were measured by OCT and AC-OCT with the high resolution corneal and pachymetry map procedure, respectively. The CCTs by OCT and AC-OCT were compared using paired samples t-test. The correlation of CCTs between OCT and AC-OCT were analyzed using linear regression analysis. CCT of one eye selected randomly was measured 10 times by above 2 instruments, respectively, and repeatability of 2 instruments was analyzed using coefficient of variation. [Results] The mean CCT measured by OCT was 526.0(s=29.4) μm. The mean CCTs of Min-CCT, Max-CCT, Mean-CCT in 2mm area of central corneal measured by pachymetry map procedure, and by high resolution corneal procedure. The values of AC-OCT were 512.6(s=31.7) μm,522.0(s=32.3) μm,515.0(s=31.7) μm, and 518.9(s=31.1) μm, respectively. The CCT by OCT was significant thicker than that of CCTs by AC-OCT were 13.3(s=5.9) μm(P=0.000);3.9(s=6.3)μm(P=0.002);11.0(s=5.9) μm(P=0.000);7.0(s=6.4) μm(P=0.000),respectively. There were positive correlationship between CCT by OCT and by AC-OCT (rOCT-AC-OCT min=0.987,rOCT-AC-OCT Max=0.987,rOCT-AC-OCT Mean=0.988,rOCT-AC-OCT Flap=0.986,P=0.000). The coefficient of variation of CCT by OCT was 0.67%, that of minimum-CCT, maximum-CCT, mean-CCT in 2 mm area of central corneal measured by pachymetry map, and by high resolution corneal AC-OCT were 0.23%,0.48%,0.20%, and 0.37%, respectively. [Conclusions] The mean CCT measured by OCT is thicker than that of by AC-OCT. There is excellent correlationship between two kinds of OCTs. The repeatability of CCT by AC-OCT is better than that of by OCT.更多还原