血清胆红素和尿酸水平与冠心病的关系

【摘要】 目的探讨患者血清胆红素和尿酸水平与冠心病(coronary heart disease,CHD)的关系。方法将150例患者按冠状动脉造影结果分为CHD组(83例)和非CHD组(67例,包括冠脉轻度狭窄组,20例;冠脉正常组47例)。采清晨空腹静脉血测定血清胆红素和尿酸水平,比较两组间的血清胆红素和尿酸水平,分析血清胆红素、尿酸水平与冠脉病变程度及病变范围的关系。结果CHD组血清总胆红素和直接胆红素水平差异有统计学意义(P<0·01,P<0·05),且随着CHD组冠状动脉病变支数的增多,血清胆红素水平明显降低(P<0·05)。血清总胆红素和直接胆红素水平越低,CHD发病率越高(P<0·01),病变程度越重,范围越大。血清尿酸水平差异有统计学意义(P<0·01),血清尿酸水平越高,CHD发病率越高,病变程度越重,冠脉病变支数越多(P<0·01),范围越大。结论低浓度血清胆红素水平和高浓度的血清尿酸水平与CHD的病变程度、病变范围具有一定的相关性。更多还原

【Abstract】 Objective To observe the relationship between serum bilirubin and uric acid levels and cornary heart disease(CHD).Methods 150 patients were divided into CHD group(83 cases) and control group(67cases,including lightly stenosis group 20 cases and normal group 67 cases) according to the result of coronary arteriography.Blood samples were collected from peripheral vein with empty stomach in the morning and the levels of serum bilirubin and uric acid was measured.The levels of serum bilirubin and uric acid were compared between the two groups.At the same time the relationship between serum bilirubin and uric acid level and the extent and range of the pathological process was analyzed.Results The levels of serum total bilirubin and direct bilirubin were significantly lower than those in the normal group.uric acid were observed between CHD group and the control group(P<0.01,P<0.05),and the level of serum bilirubin became lower when the coronary pathological process became rising(P<0.05).The lower the levels of serum total bilirubin and direct bilirubin were,the higher of the CHD disease incidence was with heavier extent and bigger range of pathological process(P<0.01).The levels of serum uric acid were much higher in CHD group than those in the normal group(P< 0.01),and the higher the levels of serum uric acid were,the higher of the CHD disease incidence was with heavier extent and bigger range of pathological process(P<0.01).Conclusion Low level of serum bilirubin and high level of serum uric acid were related to the extent and range of CHD pathological process.更多还原