【摘要】 目的比较比索洛尔在不同心律状态下的慢性充血性心力衰竭(CHF)患者治疗剂量耐受情况。方法对142例CHF患者[其中窦性心律(窦律)102例,心房颤动(房颤)心律28例,起博器心律12例]在常规心力衰竭(心衰)治疗基础上口服比索洛尔,逐渐加量至目标剂量。治疗目标分别为①心室率下降到50~65次/min(不低于50次/min);②稍加剂量心功能下降1级;③收缩压不低于90mmHg(1mmHg=0.133kpa);④达最大剂量10mg/d。结果窦律者比索洛尔平均剂量低于房颤和起博器心律者[(4.25±0.75)mg/d(7.14±1.20)mg/d和(7.23±1.22)mg/d,P<0.01];窦律者达心率目标的平均剂量低于达心衰的目标剂量,房颤者心率和心衰的目标剂量相当,而3种不同心律患者达心衰目标剂量无明显差异(P>0.05)。结论不同心律的CHF患者对比索洛尔的耐受性均较好,且房颤和起博器心律者好于窦律患者。更多还原

【Abstract】 Objective To compare the tolerance of Bisoprolol in congestive heart failure (CHF) patients with different cardial rhythm. Methods Bisoprolol was orally administealed in CHF Patients [102 with sinus rhythm, 28 with atrial fibrillation (AF) rhythm and 12 with cardiac pacing rhythm] at the basis of regular regimen and the dosage was increasingly added to the target dose. The target doses were respectively defined as : ①heart rate to 50-65 bpm (no less than 50 bpm); ②cardiac function worsen to next degree with dosage adding; ③systolic blood pressure no less than 90 mmHg; ④to the defined dose of (10mg/dag). Results The average dose of Bisoprolol was lower in patients with sinus rhythm than in patients with AF rhythm and cardiac pacing thythm (4.25±0.75)mg/d VS(7.14±1.20)mg/d and (7.23±1.22)mg/d, P<0.01). The average dose to heart rate target was less than to heart failure target in patients with sinus rhythm and was almost the same in patients with AF rhythm. There was no significant difference in average dose to heart failare target among all patients with different rhythm. Conclusion The good tolerance to Bisoprolol was found in CHF patients with different cardiac rhythm and was better in patients with AF and cardiac pacing rhythm than with sinus one.更多还原