【摘要】 目的:优化粘胶分散型透皮贴剂的处方。方法:以大鼠皮肤为实验屏障,初粘力与体外透皮速率常数为评价指标,采用星点设计-效应面法优化贴剂处方中增塑剂、交联剂和促渗剂的最佳配比。结果:各指标的二项式拟合方程均优于多元线性回归方程,优化处方中增塑剂:交联剂:促渗剂所占比例分别为45%,2.8%,7.4%。结论:建立的模型可较好地描述该实验中因素与指标的关系,预测性良好。更多还原

【Abstract】 Objective:To optimize the preparation of drug in adhesive transdermal patch.Methods:Taking SD mouse skin as protective screen of the experiment and tackness and transdermal speed constant of vitro as evaluation index to optimize the best matching of plasticizer,cross-linking agent and penetration enhancer in transdermal patch.Results:Second-order quadratic models of index are superior to the plural linear regress equation,plasticizer:cross-linking agent:penetration enhancer is 45%∶2.8%∶7.4%.Conclusions:In this experiment,the established model can describe the relation between factor and index and the outcome of prediction is good.更多还原