【摘要】 目的:探讨肺心通对慢性肺源性心脏病(CPHD)大鼠的治疗效果及其作用机理。方法:50只Wistar大鼠,雌雄各半,随机分为空白组、模型组、肺心通高、中、低剂量组,以2%野百合碱(MCT)按60 mg/kg 1次腹腔注射复制CPHD大鼠模型。同时给模型组、肺心通高、中、低剂量组灌胃相应药物,连续用药21 d。测定大鼠血清和肺组织匀浆中一氧化氮(NO)、内皮素-1(ET-1)的含量;测定肺小动脉及支气管平滑肌血管内皮细胞生长因子(VEGF)的表达;观察肺组织病理形态学改变。结果:肺心通可显著提高CPHD模型大鼠的NO含量;降低ET-1的含量;降低大鼠肺小动脉及支气管平滑肌中VEGF的表达;改善肺组织的病理改变。结论:肺心通对CPHD大鼠有较好的治疗作用。更多还原

【Abstract】 Objective:To research the functionary mechanism and treating effect of Feixintong(FXT) on chronic pulmonary heart disease(CPHD).Methods:50 Wister rats were randomly separated into five groups:blank control group,model group,FXT groups of high,middle and low dosage,The rat model of corpulmonale was established by injecting 2% monocrotaline(60 mg/kg)i.p.At the same time,model group,FXT groups of high,middle and low dosage were separately administrated with physical saline or FXT for 21 days.NO,ET-1 and expression of VEGF in bronchi arterioles was measured.Lung tissue sections were examined to study the morphological alternations.Results:FXT could evidently improve the NO content of rat model of CPHD;reduce the ET-1 content;reduce the expression of VEGF in bronchi arterioles.Conclusions:FXT treatment is effective on rat model of CPHD.更多还原