【摘要】 目的:探讨血康口服液治疗特发性血小板减少性紫癜(idiopathic thrombocytopenic purpura,ITP)的疗效机理。方法:采用12 d每2日1次腹腔注射4倍稀释豚鼠抗鼠血小板抗血清5 mL/kg,共7次,建立小鼠ITP模型,自造模第一天开始灌胃血康口服液高、低两个剂量组共15 d。结果:血康口服液能显著提升ITP小鼠外周血小板数,促进巨核细胞向成熟方向分化效应,改善脾脏组织病理学变化。结论:血康口服液对ITP治疗安全、有效。更多还原

【Abstract】 Objective:To study the effect of Xuekang Koufuye on mice models of idiopathic thrombocytopenic purpura(ITP).Methods:Guinea pig anti-mice platelet serum(GP-APS) was diluted with saline(1∶4),and intravitreal injected(5 mL/kg) into mice once in 2 days for 15 days.Two dosage of Xuekang Koufuye was given orally to mice in 15 days since mice models of ITP were established.Results:Xuekang Koufuye can enhance the amount of platelets,promote the mature of megakaryocyte of mice significantly and improve the histological pathology of spleen.Conclusions:Xuekang Koufuye is an effective and safety medicine in treating ITP,and can be used widely in clinic.更多还原