【摘要】 目的:考查甘草皂苷与桔梗皂苷祛痰和抗炎作用的相互作用性质。方法:采用气管酚红排泌、二甲苯致耳肿胀及磷酯酶A2致足跖肿胀模型,运用改良的等高线法对两者合用的相互作用进行评价。结果:随着合用剂量的减少,相互作用评价结果呈现从拮抗到协同的趋势,在较低有效剂量范围内,表现为相加和协同的结果。结论:在固定配比下,合并效应与剂量大小密切相关。更多还原

【Abstract】 Objective:To evaluate the expectorant and anti-inflammatory effects of the combinations of saponins of Glycyrrhiza uralensis Fisch（GS） and Platycodon grandiflorum A.DC（PS）.Methods:The phenol drain model,xylene-induced mouse ear edema model and PLA₂-induced mouse paw edema model were used,and the interaction between these two agents was evaluated by modified isobologram method.Result:With the decrease of total dose,the trend of interaction from antagonism to synergism was observed,and synergism or additivity was obtained at low effective doses.Conclusion:At fixed ratio,the total dose would affect the herbal interactive effects.更多还原