【摘要】 目的:研究心肌灌注断层显像中定量分析法在冠状动脉疾病(CAD)诊断中的价值,并探讨短暂性缺血扩张(TID)对评价CAD严重程度的价值。方法:70例拟诊冠心病患者,平均年龄62.5±11.3岁。均进行潘生丁(双嘧达莫)负荷-静息99mTc-MIBI心肌灌注断层显像和冠状动脉造影检查。计算机软件自动进行定量分析,并得到TID值。结果:视觉分析法和定量分析法的敏感性、特异性、准确率、假阳性率分别为70.83%、68.18%、70.00%、17.07%和87.50%、90.91%、88.57%、4.55%。各组TID值均值:3支病变1.21±0.10;2支病变1.02±0.14;1支病变1.05±0.11;冠脉造影阴性者0.97±0.10。3支病变的TID值与阴性组比较有显著差异(P<0.01)。单支病变中狭窄程度与TID值显著相关(γ=0.619,P<0.05)。结论:定量分析法能够较视觉分析更好地确定冠状动脉疾病,并且能够确定冠状动脉狭窄部位和程度。TID值可以作为诊断冠脉疾病,尤其是严重的、广泛的冠脉病变的很有价值的指标。更多还原

【Abstract】 Objective:To investigate the diagnostic value of quantitative analysis method on myocardial perfusion imaging for coronary artery disease(CAD)and the value of transient ischemic dilation(TID)for assessing severity of CAD.Methods:Dipyridamole stress and rest 99mTc-MIBI imaging were performed in 70 patients with known angiography.Using visual analysis and computer-based quantitative analysis programs to interpret images.TID values were acquired by computer automatically.Results:The sensitivity,specificity,accuracy and false positivity of visual and quantitative analysis were 70.83%,68.18%,70.00%,17.07% and 87.50%,90.91%,88.57%,4.55%,respectively.Mean values of TID in 4 groups(groups of 3 vessels,2 vessels and single vessel lesion,normal group) were 1.21±0.10,1.02±0.14,1.05±0.11 and 0.97±0.10,respectively.There was significant difference between 3 vessels lesion and normal group(P<0.01).TID value was relative to the extent of vessel stenosis(r=0.619,P<0.05).Conclusion:Compared with visual analysis,quantitative analysis can improve diagnostic accuracy,sensitivity,specificity and confirming the site and extent of stenosis.TID value can be a useful index for diagnosing CAD,especially for severe and extensive CAD.更多还原