【摘要】 目的:了解不孕症妇女生殖道沙眼衣原体(CT)、解脲脲原体(UU)和人型支原体(MH)感染状况并分析支原体对常用抗生素的耐药性。方法:对2186例不孕症患者(不孕组)和210例早孕妇女(对照组)进行CT抗原检测和UU、MH培养及药敏试验,并对结果进行临床分析。结果:不孕组CT阳性173例,阳性率7.9%;支原体总阳性1102例,阳性率50.4%,其中UU感染987例,MH感染115例;CT、UU、MH的总感染数1275例,总感染率58.3%。对照组CT阳性率1.4%,支原体阳性率6.2%,对照组总感染率为7.6%,两组比较差异有显著性意义(P﹤0.01)。UU、MH、UU+MH培养前三位敏感的抗生素分别是交沙霉素、美满霉素、克拉霉素。耐药率最高的抗生素是喹诺酮类,居前三位的分别是司帕沙星、诺氟沙星、氧氟沙星。结论:不孕症妇女生殖道衣原体、支原体感染率显著高于正常已孕妇女,这说明生殖道衣原体、支原体感染可能是引起不孕症的原因之一;支原体对常用抗生素,特别是喹诺酮类和部分大环内酯类的敏感性下降。更多还原

【Abstract】 Objectives:To investigate the prevalence situation and antibiotic resistance of chlamydia trachomatis (CT),ureaplasma urealyticum(UU) and mycoplasma hominis(MH) in infertile female patient,and to analyze the resistant of mycoplasma to common antibiotics. Methods:The cervical secretion samples from 2186 female infertility and 210 pregnancies women were collected. Then chlamydia trachomatis antigen was detected by immunoassay. Mycoplasma (UU and MH) were isolated and tested antimicrobial susceptibility for 12 kinds of antimicrobial drugs. Results:In the trial group 173 were CT-positive at a rate of 7.9%,and 1102 were positive for the mycoplasmae at a rate of 50.4%,of which 987 were UU infections and 115 were MH infections.The number of CT,UU and MH infections totaled 1275 cases,leading to an overall infection rate of 58.3%. The top three antibiotics for drug sensitivity in the UU,MH and UU+MH cultures were josamycin,minocycline and clarithromycin.The three antibiotics,to which the pathogens were most tolerant,included ofloxacin,norofloxacin and sparfloxacin. Conclusion:The infection rate of chlamydia and mycoplasma in infertility women is obviously higher than normal pregnanted,this shows the fact that chlamydia and mycoplasma infection of genitourinary tract may be one reason of infertility.The sensitivity of mycoplasma to common antibiotics especially to quinolones and macrolides has decreased.更多还原