【摘要】 目的:探讨宫颈鳞癌组织中Survivin和p53蛋白的表达及其临床意义。方法:采用免疫组化SP法检测60例宫颈鳞癌组织中Survivin和p53蛋白的表达情况,并结合临床病理特征进行分析。结果:Survivin和p53在宫颈鳞癌中的表达阳性率分别为90%、53.33%。Survivin的表达与患者的年龄、分化程度、新辅助化疗及有无淋巴结转移无关,但与临床分期显著相关。p53蛋白的表达与患者的年龄、分化程度无关,但与临床分期、是否进行新辅助化疗及有无淋巴结转移显著相关。Survivin和p53在宫颈鳞癌中共同表达阳性率为51.67%,尤其是术前进行了新辅助化疗或伴转移的病例中,二者的共同表达阳性率更高,分别为85%和91.67%。结论:Survivin和p53可能参与了宫颈癌的演进和恶化,两者可能起协同作用。更多还原

【Abstract】 Objective:To investigate the clinical significance of the expression of Survivin and p53 in cervical carcinoma.Meth- ods:Expression of Survivin and p53 in sixty paraffin-embedded specimens of cervical carcinoma patients were examined by us- ing the immunohistochemistry method.Results:The positive expressions rates of Survivin and p53 in sixty cervical carcinoma specimens were 90%,53.33% respectively.The positive expressions of Survivin were not associated with age,differentiation grade,neoadjuvant chemotherapy and lymph node metastasis,but were highly associated with clinical stage.The positive expres- sions of p53 were not associated with age and differentiation grade,but highly associated with clinical stage,neoadjuvant chemotherapy and lymph node metastasis.The positive rate of the co-expression of Survivin and p53 in sixty specimens was 51.67%,and it was especially higher in the patients who experienced neoadjuvant chemotherapy(85%)or had lymph node metastasis(91.67%).Conclusions:The expressions of Survivin and p53 in cervical carcinoma might cooperatively play an im- portant role in the progression and deterioration of cervical carcinoma.更多还原