【摘要】 目的研究氨茶碱魔芋胶骨架片的体外释药机制。方法以氨茶碱为模型药物,采用粉末直接压片法制备氨茶碱魔芋胶骨架片,测定不同搅拌转速条件下骨架片的体外溶蚀度与释放度,分别采用零级方程和Peppas方程对释药过程中骨架片的溶蚀度和释放度数据进行处理。结果骨架片的溶蚀符合零级方程,溶蚀量随搅拌转速增加而增加;骨架片的药物释放为扩散和溶蚀协同作用,随搅拌转速增加或释药时间延长,骨架片释药过程中扩散释放所占比例下降,溶蚀释放所占比例增加。结论氨茶碱魔芋胶骨架片的释药机制为非Fick扩散,即药物扩散和骨架溶蚀协同作用。更多还原

【Abstract】 Objective To determine the release mechanism of aminophylline from konjac glucomannan(KGM) matrix tablets.Methods KGM hydrophilic matrix tablets were prepared by direct compression method with aminophylline as the model drug.The release of aminophylline and the erosion properties of matrix tablets were examined at different paddle speeds.The amount of drug release and matrix tablets erosion were confirmed in Peppas equation and zero order kinetic equation,respectively.Results The erosion of matrix tablets exhibited the zero order kinetic equation.The amount of erosion increased with the increase of rotation speed.The release of aminophylline exhibited the Peppas equation.The time extended with the increase of rotation speed,the percentage of diffusion decreased,and the erosion increased.Conclusion The release mechanism of aminophylline from KGM matrix tablets is non-Fickian release that coupled the diffusion and erosion model.更多还原